REVIEW ARTICLE: THE ROLE OF DENDRITIC CELLS IN THE CONTROL ON INNATE IMMUNITY
DOI:
https://doi.org/10.53555/eijmhs.v5i3.81Keywords:
innate inflammatory responses, T cells and B cells, adaptive immune response, innate immunityAbstract
Dendritic cells play an important role in host immunity by inducing innate inflammatory responses to pathogens, efficiently priming immature T cells, activating memory T cells and promoting B cell activation. Dendritic cells are also integral in maintaining steady- state immune homeostasis by continually presenting tissue-derived selfantigens to CD4+ and CD8+ T cells in the absence of inflammatory signals, leading to tolerance against those self-antigens. The important of innate immunity lies not only in directly confronting pathogenic and non-pathogenic insults but also in instructing the development of an efficient adaptive immune response.
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