IMPORTANCE OF EXCITOTOXICITY IN STRESS: A MINI REVIEW

Abstract

Excitotoxicity refers to the process where nerve cells are damaged or killed due to excessive stimulation by neurotransmitters, primarily glutamate. This overactivation of receptors, such as NMDA (N-methyl-D-aspartate) receptors, causes an influx of calcium ions into the neurons, leading to cell damage or death. It is a key factor in various neurodegenerative diseases and acute neurological conditions like stroke and traumatic brain injury. Many researchers suggested that chronic stress can exacerbate excitotoxicity by increasing the release of glutamate in the brain. There are numerous factors play extremely important roles in many endorsing the excitotoxicity are increased glutamate levels, vulnerability of the neurones and neuro-degeneration in the diseases like Parkinsons. Several protective measures are obtained by the review of many researches. Effective stress management, including mindfulness, exercise, and therapy, can help regulate glutamate levels and reduce the risk of excitotoxicity.Enhancing antioxidant defences through diet or supplementation may protect neurons from the oxidative stress induced by excitotoxicity.Drugs that block NMDA receptors or regulate glutamate activity are being explored as treatments for conditions associated with excitotoxicity.