DISSERTATION FOR FCPS (OBSTETRICS AND GYNECOLOGY) DROTAVERINE FOR ACCELERATION OF LABOUR IN TERMS OF CERVICAL DILATATION

Authors

  • Dr. Rubeena Aslam

DOI:

https://doi.org/10.53555/eijmhs.v9i3.187

Keywords:

Drotaverine, Control, Duration, Stage, Labour

Abstract

Background: Acceleration of labour is process of stimulating the uterus to increase the frequency, duration and intensity of contractions after the onset of spontaneous labour. Drotaverine is an effective medicine to treat spasm or twitches of the smooth muscles in the stomach and heart.

Objective: To compare the outcome for acceleration of labour in terms of mean duration of 1st stage in laboring patients receiving drotaverine versus control group.

Material & Methods

Study Design: It was randomized control trial

Setting: Department of Obstetrics and Gynecology GMC Teaching hospital Gujranwala

Duration: 6 months after the approval of synopsis i.e. from (………..) to (………)

Data collection:. The patients were divided into two groups. The results were noted in terms of duration of first stage of labour in two groups. All the collected data was entered and analyzed on SPSS version 11.

Results: The mean age of the patients was 27.47±6.66 years. Among of 248 respondents the mean duration of active stage labour in group A was respondents was 2.08±0.82 hours and in group B was 3.10±0.86 hours. Statistically significant difference found between study groups i.e. p-value=0.001.

Conclusion: Drotaverine appear to significantly helpful for acceleration of labour by reducing duration of 1st stage in laboring patients

Author Biography

Dr. Rubeena Aslam

DHQ Teaching hospital, Gujranwala

References

. Rohwer AC, Khondowe O, Young T. Antispasmodics for labour. Cochrane Database Syst Rev. 2012;8.

. Cromi A, Ghezzi F, Agosti M, Uccella S, Piazza N, Serati M, et al. Use of an antispasmodic (rociverine) to shorten the length of labor: a randomized, placebo‐controlled trial. Acta obstetricia et gynecologica Scandinavica. 2011;90(12):1371-8.

. Boubaker H, Boukef R, Claessens Y-E, Bouida W, Grissa MH, Beltaief K, et al. Phloroglucinol as an adjuvant analgesic to treat renal colic. The American journal of emergency medicine. 2010;28(6):720-3.

. Kirmani Sameera MM, et al.Efficacy of drotaverine in comparison of hyoscine butylbromide in augmentation of labour.SMHS Hospital Srinagar journal of medical sciences.2012;15(1)39-43. (3).

. Madhu C, Mahavarkar S, Bhave S. A randomised controlled study comparing Drotaverine hydrochloride and Valethamate bromide in the augmentation of labour. Archives of gynecology and obstetrics. 2010;282(1):11-5.

. Aziz M. Comparative study of tramadol hydrochloride and drotavarine hydrochloride on cervical dilatation in active labour. International Journal of Scientific & Technology Research. 2014;3(4):338-47.

. nichd.nih. Pregnancy: Condition Information. 2016 [cited 2016]; Available from:

https://www.nichd.nih.gov/health/topics/pregnancy/conditioninfo/Pages/default.aspx.

. Wylie L. Essential anatomy and physiology in maternity care: Elsevier Health Sciences; 2005.

. Polin RA, Fox WW, Abman SH. Fetal and neonatal physiology: Elsevier Health Sciences; 2011.

. nichd.nih. What are some common signs of pregnancy? 2016 [cited 2016]; Available from:

https://www.nichd.nih.gov/health/topics/pregnancy/conditioninfo/Pages/signs.aspx.

. nichd.nih.gov. How do I know if I’m pregnant? 2016 [cited 2016]; Available from:

https://www.nichd.nih.gov/health/topics/pregnancy/conditioninfo/Pages/know.aspx.

. wikipedia.org. Pregnancy. 2016 [cited 2016]; Available from: https://en.wikipedia.org/wiki/Pregnancy.

. Organization WH. Injuries and violence: the facts 2014. 2014.

. Sedgh G, Singh S, Hussain R. Intended and unintended pregnancies worldwide in 2012 and recent trends. Studies in Family Planning. 2014;45(3):301-14.

. Naghavi M, Wang H, Lozano R, Davis A, Liang X, Zhou M, et al. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2015;385(9963):117-71.

. Chitty LS, Hill M, White H, Wright D, Morris S. Noninvasive prenatal testing for aneuploidy–ready for prime time? American journal of obstetrics and gynecology. 2012;206(4):269-75.

. Rank O. Birth Trauma. New York: Robert Brunner; 1952.

. Rank O. The Myth of the Birth of the Hero and Other Writings (Philip Freund, ed.). F Robbins and Smith Ely Jellife, trs, New York, Vintage. 1932:94.

. Renggli F. Tracing the Roots of Panic to Prenatal Trauma. Panic: Origins, Insight, and Treatment. 2002(63):15.

. Fodor N. The search for the beloved: a clinical investigation of the trauma of birth and pre-natal conditioning: Hermitage Press; 1949.

. Wikipedia. Prenatal and perinatal psychology. 2016 [cited 2016]; Available from:

https://en.wikipedia.org/wiki/Prenatal_and_perinatal_psychology.

. Leboyer F. Childbirth without violence. London: Wildwood House. 1975.

. McCarty WA. Welcoming Consciousness: Supporting Babies' Wholeness from the Beginning of Life: an Integrated Model of Early Development: Wondrous Beginnings Publishing; 2009.

. McCarty WA. Supporting babies' wholeness in the 21st century: an integrated model of early development. Journal of Prenatal & Perinatal Psychology & Health. 2006;20(3):187.

. cia.gov. The world Fact book. 2016 [cited 2016]; Available from: https://www.cia.gov/library/publications/the-world-factbook/rankorder/2127rank.html.

. Statistics NCfH, Research NCfHS. Health, United States: US Department of Health, Education, and Welfare, Public Health Service, Health Resources Administration, National Center for Health Statistics; 2011.

. Webster M. definitions-Pregnancy report a problem. 2011.

. Mock CN, Donkor P, Gawande A, Jamison DT, Kruk ME, Debas HT. Essential surgery: key messages from Disease Control Priorities. The Lancet. 2015;385(9983):2209-19.

. Wikipedia. Pregnancy. 2016 [cited 2016]; Available from: https://en.wikipedia.org/wiki/Pregnancy.

. Martin E. Concise colour medical dictionary: Oxford University Press; 2015.

. Wikipedia. Childbirth. 2016 [cited 2016]; Available from: https://en.wikipedia.org/wiki/Childbirth.

. Hanushek EA. Teacher deselection. Creating a new teaching profession. 2009;168:172-3.

. Olsen O, Clausen JA. Planned hospital birth versus planned home birth. The Cochrane Library. 2012.

. De Fossard E, Bailey M. Communication for Behavior Change: Volume Lll: Using Entertainment–Education for Distance Education: SAGE Publications India; 2016.

. Memon HU, Handa VL. Vaginal childbirth and pelvic floor disorders. Women's health. 2013;9(3):265-77.

. McDonald SJ, Middleton P, Dowswell T, Morris PS. Effect of timing of umbilical cord clamping of term infants on maternal and neonatal outcomes. Evidence‐Based Child Health: A Cochrane Review Journal. 2014;9(2):303-97.

. Hofmeyr GJ, Hannah M, Lawrie TA. Planned caesarean section for term breech delivery. The Cochrane Library. 2015.

. Molina G, Weiser TG, Lipsitz SR, Esquivel MM, Uribe-Leitz T, Azad T, et al. Relationship between cesarean delivery rate and maternal and neonatal mortality. JAMA. 2015;314(21):2263-70.

. Martin RJ, Fanaroff AA, Walsh MC. Fanaroff and Martin's neonatal-perinatal medicine: diseases of the fetus and infant: Elsevier Health Sciences; 2010.

. Callister LC, Khalaf I, Semenic S, Kartchner R, Vehvilainen-Julkunen K. The pain of childbirth: perceptions of culturally diverse women. Pain Management Nursing. 2003;4(4):145-54.

. Hodnett ED. Pain and women's satisfaction with the experience of childbirth: a systematic review. American journal of obstetrics and gynecology. 2002;186(5):S160-S72.

. Meyer D. Selective serotonin reuptake inhibitors and their effects on relationship satisfaction. The Family Journal. 2007;15(4):392-7.

. Zlotnick C, Johnson SL, Miller IW, Pearlstein T, Howard M. Postpartum depression in women receiving public assistance: pilot study of an interpersonal-therapy-oriented group intervention. American Journal of Psychiatry. 2001;158(4):638-40.

. Chabrol H, Teissedre F, Saint-Jean M, Teisseyre N, Sistac C, Michaud C, et al. [Detection, prevention and treatment of postpartum depression: a controlled study of 859 patients]. L'Encephale. 2001;28(1):65-70.

. Wikipedia. Cervical dilation. 2017 [cited 2017]; Available from: https://en.wikipedia.org/wiki/Cervical_dilation.

. Aaron E Goldberg. Cervical Ripening. 2015 [cited 2017]; Available from:

http://emedicine.medscape.com/article/263311-overview#a2.

. Wikipedia. Childbirth. 2017 [cited 2017]; Available from: https://en.wikipedia.org/wiki/Childbirth.

. Pillitteri A. Chapter 15: Nursing Care of a Family During Labor and Birth. Maternal & Child Health Nursing: Care of the Childbearing & Childrearing Family. 2010;350.

. Kupferminc M, Lessing J, Yaron Y, Peyser M. Nifedipine versus ritodrine for suppression of preterm labour. BJOG: An International Journal of Obstetrics & Gynaecology. 1993;100(12):1090-4.

. Jokic M, Guillois B, Cauquelin B, Giroux JD, Bessis JL, Morello R, et al. Fetal distress increases interleukin‐6 and interleukin‐8 and decreases tumour necrosis factor‐α cord blood levels in noninfected full‐term neonates. BJOG: An International Journal of Obstetrics & Gynaecology. 2000;107(3):420-5.

. Lyrenäs S, Clason I, Ulmsten U. In vivo controlled release of PGE2 from a vaginal insert (0.8 mm, 10 mg) during induction of labour. BJOG: An International Journal of Obstetrics & Gynaecology. 2001;108(2):169-78.

. Giacalone PL, Vignal J, Daures JP, Boulot P, Hedon B, Laffargue F. A randomised evaluation of two techniques of management of the third stage of labour in women at low risk of postpartum haemorrhage. BJOG: An International Journal of Obstetrics & Gynaecology. 2000;107(3):396-400.

. Hantoushzadeh S, Alhusseini N, Lebaschi AH. The effects of acupuncture during labour on nulliparous women: a randomised controlled trial. Australian and New Zealand Journal of Obstetrics and Gynaecology. 2007;47(1):26-30.

. Reiter RJ, Tan DX, Korkmaz A, Rosales-Corral SA. Melatonin and stable circadian rhythms optimize maternal, placental and fetal physiology. Human reproduction update. 2013;20(2):293-307.

. Rouse DJ, Weiner SJ, Bloom SL, Varner MW, Spong CY, Ramin SM, et al. Second-stage labor duration in nulliparous women: relationship to maternal and perinatal outcomes. American journal of obstetrics and gynecology. 2009;201(4):357. e1-. e7.

. Weeks AD. The retained placenta. Best practice & research Clinical obstetrics & gynaecology. 2008;22(6):1103-17.

. Ball H. Active management of the third state of labor is rare in some developing countries. International Perspectives on Sexual and Reproductive Health. 2009;35(2):105.

. Stanton C, Armbruster D, Knight R, Ariawan I, Gbangbade S, Getachew A, et al. Use of active management of the third stage of labour in seven developing countries. Bulletin of the World Health Organization. 2009;87(3):207-15.

. Gjerdingen D, Froberg D. The fourth stage of labor: the health of birth mothers and adoptive mothers at six-weeks postpartum. Family medicine. 1991;23(1):29-35.

. Organization WH. WHO recommendations on postnatal care of the mother and newborn: World Health Organization; 2014.

. Wikipedia. Drotaverine. 2017 [cited 2017]; Available from: https://en.wikipedia.org/wiki/Drotaverine.

. Sinhasane H, Nishty G. A comparative study on the efficacy of drotaverine and valethamate on cervical dilatation during labour. International Journal of Reproduction, Contraception, Obstetrics and Gynecology. 2017;6(2):423-6.

. Thapa M, Saha R, Pradhan A, Shrestha S. Effectiveness of drotaverine hydrochloride in progression of labour. Nepal Journal of Obstetrics and Gynaecology. 2007;2(2):9-11.

. Sharma J, Pundir P, Kumar A, Murthy N. Drotaverine hydrochloride vs. valethamate bromide in acceleration of labor. International Journal of Gynecology & Obstetrics. 2001;74(3):255-60.

. Singh K, Jain P, Goel N, Saxena A. Drotaverine hydrochloride for augmentation of labor. International Journal of Gynecology & Obstetrics. 2004;84(1):17-22.

. Kaur D, Kaur R. Comparison of drotaverine and epidosin in first stage of labor. J Obstet Gynaec India. 2003;53(5):449-52.

. Khosla A, Bala I, Dahiya K, Sangwan K. A comparative study of the efficacy of valethamate bromide with drotaverine in normal labor. J Obstet Gynecol India. 2003;53(6):568-70.

. Gupta B, Nellore V, Mittal S. Drotaverine hydrochloride versus hyoscine‐N‐butylbromide in augmentation of labor. International Journal of Gynecology & Obstetrics. 2008;100(3):244-7.

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Published

2023-12-16