MAGNITUDE AND PATTERN OF HEPATITIS B CARRIERS IN THE GENERAL POPULATION AT A TERTIARY CARE HOSPITAL.

Authors

  • Dr Giridhara Upadhyaya P M
  • Dr Supriya Christopher
  • Ms Ramya Jayasimha

DOI:

https://doi.org/10.53555/eijmhs.v2i2.111

Abstract

Hepatitis B virus (HBV) is a parenterally transmitted virus that has assumed great clinical significance of late. The clinical presentation of HBV ranges from asymptomatic or unapparent infection to acute liver failure. Subsequent to acute manifestations, there is generally elimination of the virus by the body’s immune processes within 6 months, but the crux of the issue lies with the individuals who remain chronically infected, who could progress on to more severe forms of hepatic disease like cirrhosis and carcinoma, or may remain asymptomatic in the form of a carrier state 

References

.Shepard CW, Simard EP, Finelli L, Fiore AE, Bell BP. Hepatitis B virus infection: epidemiology andaccination.

Epidemiol Rev. 2006; 28: 112-25.

.Koff RS. Review article: vaccination and viral hepatitis-current status and future prospects. Aliment Pharmacol

Ther. 2007 Nov 15; 26(10):1285-92.

.Viral Hepatitis Prevention Board. Antwerp VHPB Report. Editorial. Control of viral hepatitis in Europe.Viral

Hepatitis. 1996; 4(2). Web. Oct 1. 2015.http://hgins.uia.ac.be/esoc/VHPB/vhv4n2.html

.Hunt C M, McGill J M, Allen M I, Condereay L D. Clinical relevance of hepatitis B viral mutations. Hepatology

; 31:1037-44.

.Gerlich WH. Medical virology of hepatitis B: how it began and where we are now. Virol J. 2013 Jul 20; 10: 239.

.Dow B C, Macvarish I, Barr A, Crawford R J, Mitchell R. Significance of tests for HBeAg and anti-HBe in HBsAg

positive blood donors. J Clin Pathol 1980; 33:11061109.

.World Health Organisation. Children's Vaccines-Safety First. Geneva: WHO; 1999.

.Batham A, Narula D, Toteja T, Sreenivas V, Puliyel JM. Sytematic review and metaanalysis of prevalence of

hepatitis B in India. Indian Pediatr. 2007 Sep; 44(9): 663-74.

.Arankalle V A, Chadha M S, Gandhe S S. HBsAg positivity among rural populations of Pune (1982-1998). Indian

J of Gastroenterol, 1999 Mar; 18(Supp 1): S27.

.Rajani M and Jais M. Magnitude and Pattern of Hepatitis B Infection in Clinically Suspected InfectiousHepatitis

at a Tertiary Care Hospital in Urban India. J Glob Infect Dis. 2014 Jul-Sep; 6(3): 105–108.

.Van Damme P, Moiseeva A, Marichev I, Kervyn A-D, Booy R, Kuriyakose S, Brockway A, Ng S-P, Leyssen M,

Jacquet J-M. Five years follow-up following two orthree doses of a hepatitis B vaccine in adolescents aged 11-15years: a randomized controlled study. BMC Infect Dis. 2010; 10: 357.

."HepatitisB."WHO.Web.7Oct.2015.http://www.who.int/mediacentre/factsheets/fs204/en/

.Margolis HS, Alter MJ, Hadler SC. Hepatitis B: evolving epidemiology and implications for control. Semin Liver

Dis. 1991 May; 11(2):84-92.

.Lahariya C, Subramanya BP, Sosler S. An assessment of hepatitisB vaccine introduction in India: Lessons for roll

out and scale up of new vaccines in immunization programs. Indian J Public Health. 2013 Jan-Mar; 57(1):8-14.

."Indian Pediatrics-Editorial."Indian Pediatrics-Editorial. Web. 7 Oct. 2015.

http://indianpediatrics.net/nov2001/nov-1335-1338.htm

.Prasad M, Thomas R, Devaraj. Prevalence of hepatitis B virus in acute hepatitis in south India. Indian J of

Gastroenterol, 1999 Mar; 18(Supp1): S28.

.Banerjee A, Chakravarty R, Mondal PN, Chakraborty MS. Hepatitis B virus genotype D infection among antenatal

patients attending a maternity hospital in Calcutta, India: assessment of infectivity status. Southeast Asian J TropMed Public Health.2005 Jan; 36(1):203-6.Sacher M, Unger FD, Eder G. Vertical hepatitis B transmission by anti-HBe positive hepatitis B carrier mothers. Padiatr Padol. 1986; 21(2):141-6.

.Okada K, Kamiyama I, Inomata M, Imai M, Miyakawa Y. e antigen and anti-e in the serum of asymptomatic carrier

mothers as indicators of positive and negative transmission of hepatitis B virus to their infants. N Engl J Med. 1976Apr 1; 294(14):746-9.

.Lamtha SC, Dixit VK, Jain AK, Kumar M, Tripathi MK, Kaushik P, Goyal S, Ghosh J, RungtaS. Correlation of

age and hepatitis B virus DNA levels with histological activity in HBeAg negative chronic hepatitis B patients.Trop Gastroenterol. 2014 JulSep; 35(3):152-6.

.Seiz PL, Slanina H, Ziebuhr J, Gerlich WH, Glebe D, Schüttler CG. Studies of nosocomial outbreaks of hepatitis

B in nursing homes in Germany suggest a major role of hepatitis B e antigen expression in disease severity andprogression. Int J Med Microbiol. Web. 2015 Aug 21.

Downloads

Published

2016-06-27