METACHROMATIC LEUKODYSTROPHY: ABOUT 04 CASES AND REVIEW OF THE LITERATURE

Authors

  • Leila kartout Pediatrics resident
  • Fatima zohra ouadghiri pediatrician, Specialist in neuropediatrics
  • Nour Mekaoui Assistant professor of pediatrics
  • Lamya Karboubi Professor of pediatrics
  • Badr Sououd Benjelloun Dakhama Professor of pediatrics: University Mohammed Vth Souissi, Rabat, Morocco

DOI:

https://doi.org/10.53555/eijmhs.v2i1.106

Keywords:

Metachromatic leukodystrophy, arylsulphatase a, demyelinisation

Abstract

Metachromatic leukodystrophy (MDL) is a hereditary lysosomal inheritance disorder with autosomal recessive transmission. It is due to the deficiency of the enzyme arylsulphatase A or it’s activating protein soposin B. It can occur at any age, but the infant form is the most frequent. The diagnosis is based mainly on data from brain magnetic resonance imaging and the arylsulfatase a dosage. We report a serie of 04 cases collected in the pediatric department at Rabat's children's hospital, allowing us to know the clinical and paraclinical characteristics of the disease, as well as the current situation in the field of therapeutic

References

.Southern E.M :Detection of specific sequences Among DNA fragments separates by electrophoresis : J.Mol.Biol.,

, n°98, p.503-17

.Bellettato CM, Scarpa M. Pathophysiology of neuropathic lysosomal storage disorders. J Inherit Metab Dis 2010;

: 347-62

.heim P, Claussen M, Hoffmann B, et al. Leukodystrophy incidence in germany. American journal of medical

genetics 1997;71:475-8

.D.P Germaina, C.Boucly, R.Y. Carlier, E. Caudron, P. Charliere et al.Therapies enzymatiques substitutives des

maladies lysosomales.La revue de Medecine interne 31 (2010) S279S288.e3: 13

.Ozkara H.A, Topçu M. Sphingolipidoses in turkey Brain Dev. 2004;26:363-366

.F.Sedel, J-C.Turpin, N.Baumann. Neurological presentations of lysosomal diseases in adult patients.rev Neurol

(paris) 2007; 163: 10, 919-29.

.kendall BE.disorders of lysosomes,peroxysomes and mitochondria.AJNR Am j neuroradiol 2000; 21: 1099-109

.Barth.ML, Ward.C, Harris.A, Saad. A, Fensom.A.Frequency of arylsulphatase a pseudodeficiency associated

mutations in healthy population. J.Med.Genet.vol.31, 667-671, 1994

.F.Mathes, S.Stroobants, D.Gerlach, C.Wohlenberg, et al. Efficacy of enzyme replacement therapy in an aggravated

mouse model of metachromatic leukodystrophy declines with age. Hum Mol Genet.2012, 21(11):2599-609

.Dali.C, Lund.AM.Therapie enzymatique substitutive par intraveineuse pour la leukodystrophie metachromatique

(MLD).Congrès Annual Clinical Genetics Meeting, Tampa, Floride (USA), 25-29 mars 2009.

.Clinical trial of gene therapy in metachromatic leukodystrophy.Available on

www.sanraffaele.org/msessa_eng.html

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Published

2016-03-27