VITAMIN D DEFICIENCY AND PSYCHOLOGICAL WELL-BEING IN KERALA: A SYSTEMATIC REVIEW OF MENTAL HEALTH OUTCOMES, EMOTIONAL RESILIENCE, COGNITIVE REAPPRAISAL, NEUROTICISM, AND LOCUS OF CONTROL

Authors

  • Sajithkumar K.S Department of psychology, Desh Bhagat University, Mandi Gobingarh, Punjab.-147301
  • Prof. (Dr.) Vipul Vithal Department of psychology, Desh Bhagat University, Mandi Gobingarh, Punjab.-147301

DOI:

https://doi.org/10.69980/8dba3w66

Keywords:

Vitamin D deficiency, psychological well-being, mental health, emotional resilience, cognitive reappraisal, neuroticism, locus of control, depression, anxiety, Kerala

Abstract

Vitamin D deficiency has emerged as a major public health concern across the world, affecting individuals across age, gender, region, and socioeconomic status. Although vitamin D has traditionally been understood in relation to calcium absorption, bone mineralization, and skeletal health, recent research has increasingly emphasized its role in brain functioning, emotional regulation, cognitive processes, immune modulation, and psychological well-being. The presence of vitamin D receptors in several brain regions involved in mood regulation, stress response, memory, and executive functioning has encouraged growing scholarly interest in the psychological implications of vitamin D deficiency. India presents a unique public health paradox because vitamin D deficiency remains highly prevalent despite abundant sunlight exposure. Kerala, a tropical state with year-round sunlight and relatively strong health indicators, offers a particularly important context for examining this paradox. Changing lifestyles, indoor occupations, urbanization, academic pressures, reduced outdoor activity, dietary transitions, and sun-avoidance behaviors may contribute to persistent vitamin D deficiency among Kerala populations. This systematic review aims to synthesize existing literature on the association between vitamin D deficiency and psychological well-being, with specific attention to depression, anxiety, emotional resilience, cognitive reappraisal, neuroticism, and locus of control. The review adopts a systematic literature-based approach guided by PRISMA principles and draws upon studies published between 2000 and 2024. Existing evidence suggests that low vitamin D status is associated with increased depressive symptoms, anxiety, psychological distress, cognitive vulnerability, reduced emotional resilience, maladaptive emotion regulation, and poorer quality of life. However, Kerala-specific psychological research remains limited. The review highlights the need for interdisciplinary research integrating nutrition, psychology, psychiatry, and public health. Addressing vitamin D deficiency may offer a low-cost, preventive strategy for improving psychological well-being and mental health outcomes.

References

1.Anglin, R. E. S., Samaan, Z., Walter, S. D., & McDonald, S. D. (2013). Vitamin D deficiency and depression in adults: Systematic review and meta-analysis. British Journal of Psychiatry, 202(2), 100–107.

2.Berk, M., Williams, L. J., Jacka, F. N., O’Neil, A., Pasco, J. A., Moylan, S., Allen, N. B., Stuart, A. L., Hayley, A. C., & Byrne, M. L. (2013). So depression is an inflammatory disease, but where does the inflammation come from? BMC Medicine, 11(1), 200.

3.Bivona, G., Agnello, L., Bellia, C., Iacolino, G., Scazzone, C., Lo Sasso, B., & Ciaccio, M. (2019). Non-skeletal activities of vitamin D: From physiology to brain pathology. Medicina, 55(7), 341.

4.Cannell, J. J., Hollis, B. W., Zasloff, M., & Heaney, R. P. (2008). Diagnosis and treatment of vitamin D deficiency. Expert Opinion on Pharmacotherapy, 9(1), 107–118.

5.Casseb, G. A., Kaster, M. P., & Rodrigues, A. L. S. (2019). Potential role of vitamin D for the management of depression and anxiety. CNS Drugs, 33(7), 619–637.

6.Eyles, D. W., Burne, T. H. J., & McGrath, J. J. (2013). Vitamin D and brain development. Frontiers in Neuroendocrinology, 34(1), 47–64.

7.Fernandes de Abreu, D. A., Eyles, D., & Féron, F. (2009). Vitamin D, a neuro-immunomodulator. Frontiers in Neuroendocrinology, 30(3), 259–281.

8.Ganji, V., Milone, C., Cody, M. M., McCarty, F., & Wang, Y. T. (2010). Serum vitamin D concentrations are related to depression in young adult US population. International Archives of Medicine, 3(1), 29.

9.Gowda, U., Mutowo, M. P., Smith, B. J., Wluka, A. E., & Renzaho, A. M. N. (2015). Vitamin D supplementation to reduce depression. Nutrition, 31(3), 421–429.

10.Harinarayan, C. V., & Joshi, S. R. (2009). Vitamin D status in India. Journal of the Association of Physicians of India, 57, 40–48.

11.Holick, M. F. (2007). Vitamin D deficiency. New England Journal of Medicine, 357(3), 266–281.

12.Holick, M. F. (2017). The vitamin D deficiency pandemic. Nutrition Reviews, 75(1), 4–5.

13.Ju, S. Y., Lee, Y. J., & Jeong, S. N. (2013). Serum vitamin D levels and depression. Journal of Nutrition, Health and Aging, 17(5), 447–455.

14.Kar, S. K., Menon, V., & Suthar, N. (2020). Vitamin D and depression: A review. Indian Journal of Psychological Medicine, 42(1), 11–21.

15.Kerr, D. C. R., Zava, D. T., Piper, W. T., Saturn, S. R., Frei, B., & Gombart, A. F. (2015). Associations between vitamin D levels and depressive symptoms. Psychiatry Research, 227(1), 46–51.

16.Lange, N. E., Litonjua, A., Hawrylowicz, C., & Weiss, S. (2012). Vitamin D, immune function and asthma. Current Opinion in Allergy and Clinical Immunology, 12(2), 181–186.

17.Milaneschi, Y., Shardell, M., Corsi, A. M., et al. (2010). Serum 25-hydroxyvitamin D and depressive symptoms. Journal of Clinical Endocrinology & Metabolism, 95(7), 3225–3233.

18.Mizwicki, M. T., & Norman, A. W. (2009). Vitamin D steroid hormone. Nutrition Reviews, 67(1), 17–29.

19.Mousa, A., Naderpoor, N., de Courten, M. P. J., et al. (2018). Vitamin D and symptoms of depression in overweight adults. Nutrients, 10(8), 1111.

20.Palacios, C., & Gonzalez, L. (2014). Vitamin D deficiency worldwide. Journal of Steroid Biochemistry and Molecular Biology, 144, 138–145.

21.Parker, G. B., Brotchie, H., & Graham, R. K. (2017). Vitamin D and depression. Journal of Affective Disorders, 208, 56–61.

22.Patrick, R. P., & Ames, B. N. (2014). Vitamin D hormone regulates serotonin synthesis. FASEB Journal, 28(6), 2398–2413.

23.Penckofer, S., Kouba, J., Byrn, M., & Estwing Ferrans, C. (2010). Vitamin D and depression. Journal of Psychiatric and Mental Health Nursing, 17(7), 651–657.

24.Sathish, T., Kannan, S., Sarma, P. S., Razum, O., Thankappan, K. R., & Oldenburg, B. (2012). Prevalence of vitamin D deficiency among adults in Kerala. Indian Journal of Endocrinology and Metabolism, 16(Suppl 2), S306–S311.

25.Spedding, S. (2014). Vitamin D and depression: A systematic review and meta-analysis. Nutrients, 6(4), 1501–1518.

26.Valipour, G., Saneei, P., Esmaillzadeh, A., et al. (2014). Vitamin D deficiency and anxiety. Nutrition Journal, 13(1), 1–8.

27.World Health Organization. (2022). World mental health report: Transforming mental health for all. Geneva: WHO.

28.World Health Organization. (2023). Depression fact sheet. Geneva: WHO.

29.Zhang, Y., Leung, D. Y. M., Richers, B. N., et al. (2012). Vitamin D inhibits inflammatory responses. Journal of Immunology, 188(5), 2127–2135.

30.Rotter, J. B. (1966). Generalized expectancies for internal versus external control of reinforcement. Psychological Monographs, 80(1), 1–28.

31.Ryff, C. D. (1989). Happiness is everything, or is it? Journal of Personality and Social Psychology, 57(6), 1069–1081.

32.Connor, K. M., & Davidson, J. R. T. (2003). Development of a resilience scale. Depression and Anxiety, 18(2), 76–82.

33.Gross, J. J. (1998). The emerging field of emotion regulation. Review of General Psychology, 2(3), 271–299.

34.Gross, J. J., & John, O. P. (2003). Individual differences in emotion regulation. Journal of Personality and Social Psychology, 85(2), 348–362.

35.Costa, P. T., & McCrae, R. R. (1992). Revised NEO Personality Inventory Manual. Psychological Assessment Resources.

36.Lazarus, R. S., & Folkman, S. (1984). Stress, appraisal, and coping. Springer.

37.Bandura, A. (1997). Self-efficacy: The exercise of control. Freeman.

38.McEwen, B. S. (2007). Physiology and neurobiology of stress. Physiological Reviews, 87(3), 873–904.

39.Jacka, F. N. (2017). Nutritional psychiatry. Lancet Psychiatry, 4(4), 271–272.

40.Sarris, J., Logan, A. C., Akbaraly, T. N., et al. (2015). Nutritional medicine as mainstream in psychiatry. Lancet Psychiatry, 2(3), 271–274.

41.Berk, M., Jacka, F. N., Williams, L. J., & Ng, F. (2010). Lifestyle and mental health. Acta Neuropsychiatrica, 22(3), 148–152.

42.Eyles, D. W., Smith, S., Kinobe, R., Hewison, M., & McGrath, J. J. (2005). Distribution of vitamin D receptor in human brain. Journal of Chemical Neuroanatomy, 29(1), 21–30.

43.McCann, J. C., & Ames, B. N. (2008). Is there convincing evidence that vitamin D affects brain function? FASEB Journal, 22(4), 982–1001.

44.Garcion, E., Wion-Barbot, N., Montero-Menei, C., et al. (2002). New clues about vitamin D functions in the nervous system. Trends in Endocrinology & Metabolism, 13(3), 100–105.

45.Groves, N. J., McGrath, J. J., & Burne, T. H. J. (2014). Vitamin D as a neurosteroid. Molecular and Cellular Endocrinology, 382(1), 699–706.

46.Dean, A. J., Bellgrove, M. A., Hall, T., et al. (2011). Effects of vitamin D supplementation on cognition and mood. Psychopharmacology, 215(3), 537–546.

47.Jorde, R., Sneve, M., Figenschau, Y., et al. (2008). Effects of vitamin D supplementation on symptoms of depression. Journal of Internal Medicine, 264(6), 599–609.

48.Wilkins, C. H., Sheline, Y. I., Roe, C. M., et al. (2006). Vitamin D deficiency and cognition. American Journal of Geriatric Psychiatry, 14(12), 1032–1040.

49.Annweiler, C., Schott, A. M., Allali, G., et al. (2010). Vitamin D and cognitive performance. Neurology, 74(1), 27–32.

50.Berridge, M. J. (2017). Vitamin D and depression. Cell Calcium, 63, 11–14.

51.Koduah, P., Paul, F., & Dörr, J. M. (2017). Vitamin D in psychiatric disorders. Frontiers in Psychiatry, 8, 219.

52.Menon, V., Kar, S. K., & Suthar, N. (2020). Vitamin D and mental health. Indian Journal of Psychological Medicine, 42(1), 11–21.

Downloads

Published

2026-06-27